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John E Scott Selected Research

Phosphotransferases (Kinase)

1/2018Discovery and characterization of an iminocoumarin scaffold as an inhibitor of MEKK2 (MAP3K2).
8/2015Identification of ponatinib and other known kinase inhibitors with potent MEKK2 inhibitory activity.
4/2013Development and validation of a high-throughput intrinsic ATPase activity assay for the discovery of MEKK2 inhibitors.
8/2004Discovery of cercosporamide, a known antifungal natural product, as a selective Pkc1 kinase inhibitor through high-throughput screening.

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John E Scott Research Topics

Disease

6Neoplasms (Cancer)
01/2018 - 11/2010
4Diarrhea
07/2014 - 11/2010
3Neoplasm Metastasis (Metastasis)
01/2018 - 04/2013
3Atherosclerosis
07/2010 - 11/2008
2Triple Negative Breast Neoplasms
01/2020 - 04/2014
2Drug-Related Side Effects and Adverse Reactions
07/2014 - 11/2010
1Breast Neoplasms (Breast Cancer)
01/2020
1Colonic Neoplasms (Colon Cancer)
11/2010
1Chronic Pain
06/2009
1Shock
08/2006
1Osteoarthritis
08/2006
1Mycoses (Diseases, Fungus)
08/2004

Drug/Important Bio-Agent (IBA)

5EnzymesIBA
07/2014 - 11/2008
4Phosphotransferases (Kinase)IBA
01/2018 - 08/2004
4Irinotecan (Camptosar)FDA LinkGeneric
07/2014 - 11/2010
3OrganophosphatesIBA
07/2010 - 11/2008
2Amoxapine (Asendin)FDA Link
07/2014 - 08/2012
2GlucuronidaseIBA
07/2014 - 08/2012
2HDL LipoproteinsIBA
07/2010 - 05/2010
1Drug CombinationsIBA
01/2020
17-ethyl-10-hydroxycamptothecin beta-glucuronideIBA
07/2014
1Dasatinib (BMS 354825)FDA Link
04/2014
1bosutinibIBA
04/2014
1IsocarboxazidFDA Link
08/2012
1NialamideIBA
08/2012
1Aryldialkylphosphatase (Paraoxonase)IBA
05/2010
1Protein Isoforms (Isoforms)IBA
06/2009
1Aggrecans (Aggrecan)IBA
08/2006
1beta-1,3-glucanIBA
08/2004

Therapy/Procedure

6Therapeutics
01/2020 - 08/2004
1Oral Administration
07/2014
1Drug Therapy (Chemotherapy)
08/2012